مَنْ أَعْرَضَ عَنْهُ ...

Whoever turns away from it,

This means whoever denies it and turns away from following its commands and instructions, while seeking guidance from other than it, then Allah will mislead him and send him on the path to Hell.

This is why Allah says,

مَنْ أَعْرَضَ عَنْهُ فَإِنَّهُ يَحْمِلُ يَوْمَ الْقِيَامَةِ وِزْرًا ﴿١٠٠﴾

Whoever turns away from it, verily, they will bear a heavy burden on the Day of Resurrection.

Burden here means sin.

This is as Allah says,

وَمَن يَكْفُرْ بِهِ مِنَ الاٌّحْزَابِ فَالنَّارُ مَوْعِدُهُ

But those of the sects that reject it, the Fire will be their promised meeting place. (11:17)

This applies generally to whoever the Qur'an reaches of the Arabs, the non-Arabs, the People of the Book and others.

This is as Allah says,

لاٌّنذِرَكُمْ بِهِ وَمَن بَلَغ

That I may therewith warn you and whomsoever it may reach. (6:19)

The Qur'an is a final warning for everyone it reaches. Whoever follows it, then he is rightly guided and whoever opposes it and turns away from it, then he is misguided. He will be wretched in this life, and he is promised that on the Day of Resurrection his abode will be the Hellfire. For this reason Allah says,